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Finally GSSG is reduced by glutathione reductase (GR) using NADPH as the electron donor

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For example, the apoptotic pores formed by BCL-2-associated X protein (BAX), B cell lymphoma-extra large (Bcl-xL) and BCL-2 antagonist/killer (BAK) release mtDNA into the cytoplasm, which activates cGASSTING signaling, induces the sustained release of inflammatory cytokines and drives the inflammatory response

Pharmaceuticals (2024) 17:497

Net release of IGF-I by muscle during endurance exercise has been observed in humans by measuring arterial venous differences in hormone concentrations (Brahm et al ., 1997)